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Fat binding complexer (Alpha-Cyclodextrin)

A naturally derived dietary fibre to help maintain healthy cholesterol and weight management

Alpha-cyclodextrin (alfadex) is a naturally sourced dietary fibre used in Nuvexa that can help maintain healthy cholesterol, triglyceride levels and weight management.

Alpha-cyclodextrin is a dietary fibre derived from corn, that can help maintain healthy cholesterol, triglyceride levels and weight management, when balanced with diet and exercise.1-4

 

Alpha-cyclodextrin is known, and branded, as FBCx (Fat Binding Complexer) –and is used in Nuvexa®.

 

Discover more about the FBCx molecule used by Flordis, how it works, and the key studies that support its benefits when used in Nuvexa.

 

Always read the label. Follow the directions of use. Packaging and product claims may vary depending on country-specific regulations. Products available in selected markets only

Alpha-cyclodextrin in history

Alpha-cyclodextrin’s fat binding effect was discovered nearly a decade ago by researchers at Wayne State University in America. Initial animal studies5,6 identified that 1 gram of alpha-cyclodextrin was able to bind and eliminate up to 9 grams of dietary fat.

These trials paved the way for further research, including a preclinical study7 suggesting that alpha-cyclodextrin may have a greater binding affinity for the ‘bad’ saturated fats in the diet.

Alpha-cyclodextrin in history

The specific dietary fibre used by Flordis: FBCx

Alpha-cyclodextrin is a water-soluble dietary fibre derived from corn starch.

 

Cyclodextrins belong to a class of molecules called ‘cage molecules’ – meaning that the core of their structure contains a cavity that can trap other molecules such as fat.

The particular structure of the alpha-cyclodextrin in Nuvexa (FBCx) means that it is able to bind fats in the diet very well – trapping a much higher ratio of fat than most other fibres.

 

The FBCx molecule has been demonstrated to bind up to 9 times its own weight in dietary fat.4

The specific dietary fibre used by Flordis: FBCx

Research on how FBCx works

  • The term ‘fibre’ comprises lots of different substances, however the characteristic of all dietary fibres is that they are resistant to digestion and therefore escape absorption into the body.

Dietary fibre tends to interfere with the absorption of certain macronutrients

(lipids and carbohydrates), so it can reduce their levels in the blood and provide some physiological benefits (i.e. support heart health).

 

FBCx makes use of this characteristic, binding fat in the diet and preventing the body from digesting and absorbing it.
 

Here’s how:

 

  • Dietary fat enters the body
  • FBCx binds to the fat and forms a complex (Each Nuvexa tablet binds up to 9g of dietary fat)
  • FBCx shields the fat molecules from the enzymes that usually break it down in the intestines, preventing digestion
  • The FBCx complex passes naturally out of the body
  • FBCx can reduce up to 54 g of dietary fat intake per day – that’s almost 500 calories a day.4
Research on how FBCx works

FBCx in clinical trials

Multiple randomised controlled trials of FBCx have demonstrated that it can help maintain healthy levels of cholesterol and triglycerides, when used with a healthy diet and lifestyle. FBCx was also shown to be well tolerated in these clinical trials.

Grunberger 2007

47 patients over 3 months

Significant improvement

vs. placebo for:

  • Total cholesterol LDL (bad) cholesterol levels Triglyceride levels Weight Adiponectin levels (involved in glucose regulation and fatty acid breakdown) Insulin sensitivity

Grunberger, et al. Diabetes Metab Res Rev 2007;23:56-62.

Comerford 2011

28 patients over 2 months

Significant improvement

vs. placebo for:

  • Total cholesterol LDL (bad) cholesterol levels Weight Insulin sensitivity

Comerford KB, et al. Obesity 2011;19:1200-1204.

Jen 2013

47 patients over 3 months

Positive Analysis

  • Up to 9:1 binding ratio of fat to FBCx Reduces dietary fat absorption by up to 54 grams Reduces calorie intake by up to 486 calories Prevention of weight gain

Jen KL, et al. Nutr Diet Suppl 2013;5:1-7.

Jarosz 2013

34 patients over 3 days*

Significant improvement

vs. placebo for:

  • Triglyceride levels (1, 2 and 3 hours after eating)

*Trial analysed the short-term effects of FBCx after 2 meals

Jarosz PA, et al. Metab Clin Exp 2013;62(10):1443-1447.

Flordis Difference

Natural healthcare products can vary considerably depending on how they are produced. Nuvexa is produced according to our 'Source to Patient' philosophy which aims to deliver a high quality and consistent extract, from batch to batch so that you can be confident that it can deliver the health benefits demonstrated in the clinical research.

This helps ensure that the natural healthcare products you are getting contains the exact ingredient, in the exact same amounts demonstrated in the clinical research. That's the Flordis difference.

FBCx & Nuvexa: A Summary

Consistent quality

Through our rigorous processes, quality controls and extensive testing we help ensure that every batch of Nuvexa can provide the health outcomes demonstrated by clinical trials.

10 years of research

Preclinical and clinical studies investigating the beneficial effect of alpha-cyclodextrin in binding fats1-9,10

4 Clinical trials

Nuvexa clinical studies support its role in maintaining healthy cholesterol and triglyceride levels and helping to maintain healthy weight1-6

Recommended worldwide

to support healthy cholesterol and triglyceride levels, and help with weight management alongside diet and exercise lifestyle changes

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Our Source to Patient philosophy

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References
  1. Grunberger, et al. Diabetes Metab Res Rev 2007;23:56-62.
  2. Comerford KB, et al. Obesity 2011;19:1200-1204.
  3. Jarosz PA, et al. Metab Clin Exp 2013;62(10):1443-1447.
  4. Jen KL, et al. Nutr Diet Suppl 2013;5:1-7.
  5. Wagner EM, et al. Metab Clin Exp 2008;57:1046-1051.
  6. Artiss JD, et al. Metab Clin Exp 2006;55:195-202.
  7. Gallaher DD, et al. FASEB J 2007;21:A730.
  8. Gentilcore D, at al. Br J Nutr 2011;106:583-587.
  9. Buckley JD, et al. Ann Nutr Metab 2006;50:108-114.
  10. McGowan MW, et al. Clin Chem 1983;29(3):538-542.

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