Soho Flordis International

African Cherry & Stinging Nettle (Urtica dioica & Pygeum africanum)

Natural relief of early BPH symptoms

Stinging nettle (Urtica dioica) and Pygeum africanum (Pruni africanae) work together in Prostatonin to provide relief of symptoms of early BPH

Stinging nettle (Urtica dioica) and Pygeum bark (Pygeum africanum) are traditionally used for mild to moderate benign prostatic hyperplasia (BPH), offering effective symptom relief with good tolerability.1-3

 

In Prostatonin®, two specific standardised extracts called PY102 from the bark of Pygeum africanum and  UR102 from the roots of Urtica dioica, have been combined to create a patented formulation.

 

Discover more about the special PY102 and UR102 extracts used by Flordis, how they work together, and the key studies that support their benefits when used in Prostatonin.

 

Always read the label. Follow the directions of use. Packaging and product claims may vary depending on country-specific regulations. Products available in selected markets only

Pygeum africanum and Urtica dioica in history

Pygeum africanum is an evergreen tree native to African forest regions.  It normally grows in the tropical and humid equatorial mountain zones. Pygeum fruit is a red berry, resembling a cherry when ripe. The bark (red, brown or gray) is the part of the plant used for medicinal purposes.

 

The origin of its use is documented back to the early 19th century. The ground bark was used in a water, tea, or milk mixture as a drug, to relieve urinary symptoms, gastric pain and urinary disorders.

 

Urtica dioica, more commonly known as stinging nettle, is native to Europe and Asia and is found widely around the world. It has leaves and stems with stinging hairs that inject a mix of chemicals that cause a stinging sensation when touched.

 

Urtica dioica has also been used medicinally for its blood-building and wound-healing properties. It has often been used in diabetic teas and for bilious complaints. Since ancient times, the stinging nettle of the plant that is present on the leaves and stems, has been used as a diuretic, astringent, expectorant and anti-haemorrhagic.

 

In modern medicine, the roots have been used for micturition problems due to prostatitis and in the first stages of BPH.4

Pygeum africanum and Urtica dioica in history

The specific extracts used by Flordis: PY 102 & UR 102

PY 102 and UR 102 are the specific extracts of Pygeum africanum and Urtica dioica used by Flordis in Prostatonin.

 

The major compounds of the Pygeum Africanum PY 102 extract are called 3-beta-sitosterol, sitosterol, fatty acids, oleanolic acids and ursolic acid.5For Urtica dioica UR102, the main constituents are coumarin and sterol derivatives.6

 

It’s important that the evidence supports the specific plant extracts - and not only the ingredient. The Urtica dioica extract used by Flordis, UR102, in combination with the Pygeum africanum extract PY102, has been well researched and has demonstrated positive results in clinical trials.7-11

 

Results from these clinical studies suggests that in early, medically confirmed BPH, this synergistic combination reduces:7-11

  • Urge to urinate
  • Feeling of incomplete emptying of the bladder
  • Frequency of micturition (urination)
The specific extracts used by Flordis: PY 102 & UR 102

How UR 102 and PY 102 work

To understand how UR102 and PY102 work together in Prostatonin, it is first useful to understand what causes benign prostatic hyperplasia.

 

Benign prostatic hyperplasia (BPH), is caused by a non-cancerous enlargement of the prostate gland. This enlarged prostate gland squeezes the urethra – resulting in many symptoms of BPH, including urgency, frequency, nocturia and weak stream.

 

There are multiple factors that may contribute to BPH, including risk factors such as age, diet and obesity, hormonal imbalance, chronic inflammation (damage to tissues) and cell proliferation (increase in the number of cells).12,13

 

Prostatonin helps to positively influence some of the processes mentioned above, to help alleviate the symptoms of BPH.7-11

 

Pygeum africanum and Urtica dioica have been studied as single extracts, and as the combination used in Prostatonin, to understand how they improve the symptoms of BPH. Their mechanisms of action  include:2,3,14-19

 

  • Anti-inflammatory action (reducing tissue damage and inflammation)
  • Anti-proliferative action (reducing unwanted cell growth)
  • Effect on hormone levels (helping to maintain the right levels of specific hormones)

Prostatonin has a powerful synergistic effect, in which the two different extracts produce a stronger effect together than the single extracts alone.18,19 It’s strength lies in its ability to carry out multiple actions, increasing the efficacy (vs. the single extracts alone), and providing a good safety profile and tolerability.

How UR 102 and PY 102 work

PY 102® and UR 102® in clinical trials

The specific extracts used in Prostatonin – known as PY102 and UR102 – have been researched together in 5 clinical trials with a good safety profile demonstrated.

Krzeski 1993

134 male patients suffering from BPH (not requiring surgery) weeks

Significant improvement

at 4 weeks for patients taking Prostatonin:

  • urine flow nocturia residual urine

Krzeski T et al. Clin Ther 1993; 15 (6), 1011-1020.

Montanari 1991

63 patients over months

Significant improvement

for all treatment groups:

  • micturition frequency nocturia urinary urgency urinary volume urinary flow The greatest improvements were seen in the Prostatonin group

Montanari E et al. Inf Arzt 1991; 6a, 593-598.

Camponovo & Maranta 1990

25 patients with diagnosed BPH weeks

Significant improvement

For patients taking Prostatonin:

  • Nocturia Micturition frequency Residual urinary volume

Camponovo F, Maranta D. Inf Arzt 1990; 12, 1121-1128.

Dieguez 2003

100 male patients with BPH over months

Significant improvement

for both treatment groups:

  • urinary flow nocturia quality of life

Dieguez V, Szemat R. Rev Ven Urol 2003; 49(1), 23-31.

Omisanjo 2012

107 patients with mild to moderate lower urinary tract symptoms from clinical BPH over weeks

Improvement

for patients taking Prostatonin:

  • 69% of patients had improved symptoms based on the International Prostate Symptom Score 44% of patients had a reduction in residual urine volume

Omisanjo O, et al. The Internet Journal of Urology 2012; Volume 9, number 2.

Always read the label. Follow the directions for use. If symptoms persist consult your healthcare professional.

Flordis Difference

Natural healthcare products can vary considerably depending on how they are produced. Prostatonin is produced according to our 'Source to Patient' philosophy which aims to deliver a high quality and consistent extract, from batch to batch so that you can be confident that it can deliver the health benefits demonstrated in the clinical research.

This helps ensure that the natural healthcare products you are getting contains the exact ingredient, in the exact same amounts demonstrated in the clinical research. That's the Flordis difference.

PY102 & UR102: A Summary

Consistent quality

Through our rigorous processes, quality controls and extensive testing we ensure that the PY102 & UR102 extracts reliably provide the desired health outcomes demonstrated by clinical trials

>25 years safety data

Post-marketing monitoring of Prostatonin indicates that it is well tolerated with no impact on sexual activity*

5 Clinical trials

 Support the combined role of PY102 & UR102 in providing relief of symptoms of early, medically confirmed BPH4-8

Recommended worldwide

to provide relief of symptoms of early BPH

Our Source to Patient philosophy

Natural healthcare products can vary considerably depending on how they are produced and the evidence supporting their benefits. Our Source to Patient philosophy is what helps make Flordis unique.

Learn more about the six precise steps we take
References
  1. Allkanjari O. Vitalone A. Life sciences 126 (2015),42-56.
  2. Pruni africanae cortex: Pygeum bark. ESCOP Scientific Foundation for Herbal Medicinal Products. Monographs, Supplement 2nd Ed. Stuttgart, Thieme Verlag. 2009; 206-212.
  3. Urticae radix: nettle root. ESCOP (European Scientific Cooperative on Phytotherapy) Monographs: the scientific foundation for herbal medicinal products. 2nd Ed.Stuttgart, Thieme Verlag. 2003; 528-535.
  4. Joshi B et al. International Journal of Green Pharmacy 2014;8.4:201-9.
  5. Schleich S, et al Planta Med. 2006 May;72(6):547-51.
  6. Franciskovic M et al. Phytotherapy Research 2017;31(8):1183-1191.
  7. Krzeski T et al. Clin Ther 1993; 15 (6), 1011-1020.
  8. Montanari E et al. Inf Arzt 1991; 6a, 593-598.
  9. Camponovo F, Maranta D. Inf Arzt 1990; 12, 1121-1128.
  10. Dieguez V, Szemat R. Rev Ven Urol 2003; 49(1), 23-31.
  11. Omisanjo O, et al. The Internet Journal of Urology 2012; Volume 9, number 2.
  12. Parsons, JK. Current Opinion in Urology 2011;21(1):1–4.
  13. Briganti A et al. European Urology Supplements 2009; 8(13):865-871.
  14. Edgar AD et al. Neurol Urodyn 2007; 26:458-463.
  15. Fischer M, Wilbert D. Wirkprüfung eines Phytopharmakons zur Behandlung der benignen Prostatahyperplasie (BPH). Rutishauser G (Ed.) 1992. Benigne Prostatahyperplasie III. Klinische und Experimentelle Urologie, Vol 22. W. Zuckwerdt, New York, pp79-84. Levin RM; Hass MA; Bellamy F; Horan P; Whitbeck K; Chow PH; Kung LS; Gosling J. J Urol (Baltimore) 2002, 167 , 2253-2259.
  16. Yoshimura Y; et al CE. Urology 2003, 61 (2):474-478.
  17. Chrubasik JE, et al. Phytomedicine 2007, 14:568-579.
  18. Hartmann RW, Mark M, Soldati F. Phytomedicine 1996; 3 (2):121-128.
  19. Dugnani S, Lucini V, Vignutelli A, Gianesello V , Scaglione F. Anti-proliferative and anti-inflammatory effects of Pygeum africanum and Urtica dioica compared to finasteride® on human cultured prostatic fibroblasts. International Conference on Advances in Plant Science, November 14-18, 2012, Chiang Mai, Thailand.