Nettle root is used for the symptomatic treatment of urinary disorders associated with Benign Prostatic Hyperplasia (BPH), an enlarged prostate

What is Urtica dioica?

Nettle root, also known as Urtica dioica, is a dioecious herbaceous perennial plant native to Eurasia and now found widely around the world, except in the arctic or tropical regions.1 

The plant can grow up to two metres tall in the summer months and dies down to the ground in winter. It has wide-spreading rhizomes and stolons that are bright yellow.2

Extracts of Urtica dioica are made from the root and underground stems (rhizomes) and then formulated into a supplement.

The history of Urtica dioica

Urtica dioica has been used medicinally to for its blood-building and wound-healing properties. It has often been used in diabetic teas and bilious complaints.1

Since ancient times, the stinging nettle of the plant that is present on the leaves and stems from broken hairs has been used as a diuretic, astringent, expectorant and anti-haemorrhagic.1 ​

In modern medicine, the roots have been used for micturition problems due to prostatitis and in the first stages of BPH.2

The specific standardised extract used by Flordis

The specific standardised Urtica dioica extract used by Flordis is known as UR102. The main constituents of the UR102 extract used by Flordis are coumarin and sterol derivatives.1

It’s important that the evidence supports the specific plant extract - and not only the ingredient. The Urtica dioica extract used by Flordis, UR102, in combination with the Pygeum africanum extract PY102, has been very well researched and has demonstrated good results in clinical trials.5,8-11

Specific standardised extracts of nettle root are used in Prostatonin® which helps to relieve symptoms of BPH.

As Flordis uses a fixed Pygeum africanum and Urtica dioica extract combination for the symptomatic treatment of BPH, this particular extract combination as a whole is considered the pharmacologically active compound.

How it works

The mechanism of action of Urtica dioica extract UR 102 has been studied in in vitro and in vivo studies and in clinical pharmacological studies in relation to BPH.

The following modes of action, related to the BPH, have been identified for Urtica dioica: anti-inflammatory activity, inhibition of the proliferation of the prostatic cells, union of Epidermal Growth Factor (EGF) to their receptors, inhibition of the 5-alpha reductase and aromatase, capacity of union of the Sexual Hormone Binding Globuline (SHBG).3

Specific modes of action of the combination between Pygeum africanum UR102 and Urtica dioica UR102 have been also conducted in two studies. An in vitro pre-clinical study has shown that the combined effect of Pygeum africanum and Urtica dioica had a significantly stronger anti-proliferation activity of prostatic cells than Pygeum africanum alone in human cultured prostatic fibroblasts with BPH. The study also found an increased anti-inflammatory action with both extracts together compared to Pygeum africanum and Urtica dioica alone.7

The multiple mechanism of action of pygeum africanum PY102 and Urtica dioica UR102 extracts have also been found to have a synergistic action that inhibit the enzymes 5-alpha-reductase and aromatase.6

References

1. Data on file.  2. Joshi B et al. Pharmacognostical review of Urtica dioica L. International Journal of Green Pharmacy 2014;8.4:201-9.  3. Urticae radix: nettle root. ESCOP (European Scientific Cooperative on Phytotherapy) Monographs: the scientific foundation for herbal medicinal products. 2nd Ed. Stuttgart, Thieme Verlag. 2003; 528-535.  4. Chrubasik JE Roufogalis BD Wagner H et al. A comprehensive review on the stinging nettle effect and efficacy profiles Part II: Urticae radix Phytomedicine 2007;14(7-8):568-79.  5. Krzeski T et al. Combined extracts of urtica dioica and pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clin Ther 1993;15(6):1011-20.  6. Hartmann RW. Mark M. Soldati F. Inhibition of 5-alpha-reductase and aromatase by PHL-00801 (Prostatonin), a combination of PY102 (Pygeum africanum) and UR102 (urtica dioica) extracts Phytomedicine 1996;3(20):121-8.  7. Dugnani S Lucini V vignutelli A et al. Anti-proliferative and anti-inflammatory effects of pygeum africanum and urtica dioica compared to finasteride on human cultured prostatic fibroblasts International Conference on Advances in Plant Science, November 14-18, 2012 Chiang Mai Thailand. Poster and abstract.  8. Montanari et al.  Benign prostatic hyperplasia. Differential therapy with phytopharmacological agents – a randomised study of 63 patients Inf Arzt 1991;6a:593-8.  9. Omisanjo O et al. Effect of the plant extracts pygeum africanum and urtica dioica on lower urinary tract symptoms due to benign prostatic hyperplasia in Nigerian men. The Internet Journal of Urology. 2012 Volume 9, number 2.  10. Camponovo F. Maranta D Benign prostate adenoma: the value of phytotherapeutics in the treatment Inf Arzt 1990;12:1121-8.  11. Dieguez V, Szemat R. Estudio clínico comparative del uso de Terazosina y extracto de Urtica dioica Y Pygeum africanum en pacientes con hiperplasia prostática benigna. 8 Meses de tratamiento. Rev Ven Urol 2003;49(1), 23-31