Alpha-cyclodextrin (alfadex) is a dietary fibre, derived from corn, which helps to maintain healthy cholesterol and triglyceride levels and helps with weight management.

What is Alpha-cyclodextrin?

Alpha-cyclodextrin is a dietary fibre derived from corn. A patented version of alpha-cyclodextrin is FBCx® which is sold as Nuvexa® or Calorease® by SFI.  FBCx is an abbreviation for “Fat Binding Complexer”.

This innovative fibre binds to dietary fat, helping to reduce up to 54g (2036 kJ / 486 Calories) of dietary fat from being absorbed by the body each day. By reducing the amount of dietary fat absorbed in the body, FBCx helps to maintain healthy cholesterol and triglyceride levels (triglycerides are a type of fat found in your blood, also known as blood lipids).

The history of alpha-cyclodextrin use

Alpha-cyclodextrin’s fat binding effect was discovered nearly a decade ago by researchers at Wayne State University in America. Pre-clinical studies2,3 identified that 1 gram of alpha-cyclodextrin is able to bind and eliminate up to 9 grams of dietary fat.

These trials paved the way for further research, including a preclinical study4 suggesting that alpha-cyclodextrin may have a greater binding affinity for saturated fats and trans fatty acids.

This innovative fibre binds to dietary fat, helping to reduce up to 54g (2036 kJ / 486 Calories) of dietary fat from being absorbed by the body each day.1

How it works

When taken with a fatty meal or snack, FBCx (alpha-cyclodextrin) binds (attaches) to dietary fats (fats in foods consumed in the diet). This forms a complex which is then passed naturally through the bowel, helping to prevent the fat from being digested and absorbed.

ModeOfAction-h.jpg

Key studies on FBCx

Over the last 10 years, research has established the supportive effects of FBCx for weight management as well as on blood cholesterol and triglyceride level management within the normal range. 

The key research findings include:

  • Comerford et al. 2011 study demonstrated that supplementation of 6 g/day of α-Cyclodextrincyclodextrin, without any diet or lifestyle changes, induced weight loss, reduced cholesterol, and increased insulin sensitivity in healthy overweight individuals.5
  • Jarosz et al. 2013 showed that α-cCyclodextrin significantly lowered acute postprandial blood triglyceride levels following the consumption of a fat-containing meal, when compared to placebo.6
  • Grunberger et al 2007 showed that  diabetic patients taking the fibre alpha-cyclodextrin maintained their weight in comparison to the placebo group over 3 months, as well as showing a reduction in their total cholesterol.7

 

 

References

1.    Jen KL et al. Nutr Diet Suppl 2013;5:1-7.
2.    Wagner EM, et al. Metab. Clin. Expt. 2008;57:1046-1051.
3.    Artiss JD, et al.. Metab. Clin. Expt 2006;55:195-202.
4.    Gallaher DD, et al. Fed Am Soc for Exp Bio Jnl 2007;21:A730.
5.    Comerford KB, et al. Obesity 2011;19:1200-1204.
6.    Jarosz PA, et al. Metab. Clin. Expt. 2013;62(10):1443-1447.
7.    Grunberger et al. Diabetes Metabolism Research and Reviews, 2007; 23:56-62.